Why treat latent tb

Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis. BMC Infect Dis. A systematic review. Ann Am Thorac Soc. Comstock GW. How much isoniazid is needed for prevention of tuberculosis among immunocompetent adults? International Union Against Tuberculosis Committee on Prophylaxis Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial.

Bull World Health Organ. Treatment of latent tuberculosis infection: a network meta-analysis. Ann Intern Med. Treatment of latent tuberculosis infection: an updated network meta-analysis. Three months of rifapentine and isoniazid for latent tuberculosis infection. N Engl J Med. Centers for Disease Control and Prevention Prevention and treatment of tuberculosis among patients infected with human immunodeficiency virus: principles of therapy and revised recommendations.

Question 1: what are the options for treating latent TB infection in children? Arch Dis Child. National survey to measure rates of liver injury, hospitalization, and death associated with rifampin and pyrazinamide for latent tuberculosis infection. Treatment of latent tuberculosis infection. In: Canadian tuberculosis standards. This document contains detailed recommendations for the treatment of LTBI. Peripheral neuritis in tuberculous patients treated with isoniazid. Am Rev Tuberc. Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic.

Adverse reactions to daily and intermittent rifampicin regimens for pulmonary tuberculosis in Hong Kong. Br Med J. Potentially serious side effects of high-dose twice-weekly rifampicin. Harris J, Jenkins P. Discoloration of soft contact lenses by rifampicin. Yew WW. Clinically significant interactions with drugs used in the treatment of tuberculosis. Drug Saf. Systematic review, meta-analysis, and cost-effectiveness of treatment of latent tuberculosis to reduce progression to multidrug-resistant tuberculosis.

Strategies for treating latent multiple-drug resistant tuberculosis: a decision analysis. PLoS One. Drug-resistant tuberculosis: a survival guide for clinicians.

Fluoroquinolone therapy for the prevention of multidrug-resistant tuberculosis in contacts. A cost-effectiveness analysis. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. A practical handbook on the pharmacovigilance of medicines used in the treatment of tuberculosis. Risk of tuberculosis in close contacts of patients with multidrug resistant tuberculosis: a nationwide cohort.

Support Center Support Center. External link. Please review our privacy policy. Caution in people with hepatic impairment; contraindicated in people with acute hepatic disease, or prior isoniazid hepatic injury. Increases serum phenytoin, carbamazepine. Increases hepatotoxicity when combined with rifampin, pyrazinamide, ethanol, and acetaminophen. Asymptomatic hepatic aminotransferase elevation, clinical symptomatic hepatitis, and peripheral neuropathy. Increases hepatotoxicity with rifampin, pyrazinamide, alcohol, and acetaminophen.

Caution in people with hepatic impairment; contraindicated in people with acute hepatic disease or prior isoniazid hepatic injury. Prior hypersensitivity reaction; caution in HIV infected individuals with careful attention paid to drug-drug interactions with antiretrovirals. Rash, orange discoloration of body fluids, hepatotoxicity, and hypersensitivity reaction, ranging from flu-like syndrome to anaphylaxis 3.

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Treatment for tuberculosis TB usually involves taking antibiotics for several months. While TB is a serious condition that can be fatal if left untreated, deaths are rare if treatment is completed. You'll be prescribed at least a 6-month course of a combination of antibiotics if you're diagnosed with active pulmonary TB, where your lungs are affected and you have symptoms.

It may be several weeks before you start to feel better. The exact length of time will depend on your overall health and the severity of your TB. However, it's important to continue taking your medicine exactly as prescribed and to complete the whole course of antibiotics.

If you stop taking your antibiotics before you complete the course or you skip a dose, the TB infection may become resistant to the antibiotics. This is potentially serious because it can be difficult to treat and will require a longer course of treatment with different, and possibly more toxic, therapies.

If you find it difficult to take your medicine every day, your treatment team can work with you to find a solution. This may include having regular contact with your treatment team at home, at the treatment clinic, or somewhere else that's more convenient. If treatment is completed correctly, you should not need any further checks by a TB specialist afterwards.

You may be given advice about spotting signs that the illness has returned, although this is rare. Extrapulmonary TB — TB that occurs outside the lungs — can be treated using the same combination of antibiotics as those used to treat pulmonary TB. If you have TB in areas like your brain or the sac surrounding your heart pericardium , you may initially be prescribed a corticosteroid such as prednisolone for several weeks to take at the same time as your antibiotics.

This will help reduce any swelling in the affected areas. As with pulmonary TB, it's important to take your medicines exactly as prescribed and to finish the whole course. Though uncommon in the UK there are strains of TB that are resistant to 2 or more antibiotics.